DOI: PubMed: Heffernan MA, Thorburn AW, Fam B, et al
In physical dependence assay (isoniazid challenge assessed at 6, 14, 42 and 72 h after conditioning medication), when compared to diazepam non-conditioned healthy mice, in diazepam conditioned mice residual anticonvulsive activity was not present already at the earliest post-conditioning interval (i.e., not different latency to isoniazid-convulsions), whereas shorter preconvulsive latencies (as physical dependence/withdrawal hallmark) were noted in diazepam conditioned mice following isoniazid challenge at 42 h and at 72 h after end of conditioning treatment
For general prevention in individuals at risk of deficiencysuch as vegans and vegetarianstypical UK recommendations include cyanocobalamin supplements providing 10-100 micrograms daily or approximately 2000 micrograms weekly
It doesnt enter systemic circulation
On arrival: Store vials in a cool, dry place away from heat and direct sunlight
