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This study was conducted in accordance with PRISMA guidelines, including observational (cohort) studies and randomized clinical trials that evaluated tirzepatide use and reported percentage changes in high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6)

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In humans, semaglutide has been demonstrated to induce an average 11.85% reduction in baseline weight among obese individuals without type-2 diabetes (Tan et al., 2022

This indicates that the hepatic effects of semaglutide are probably not the reflect of direct action of semaglutide on hepatocytes

Some jurisdictions restrict import, and marketing it for human use is broadly prohibited