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Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide

Ferroptosis can be induced by depriving cells of methionine or inhibiting the transsulfuration pathway [144, 145]

While metabolic reprogramming and mitochondrial dysfunction are known to contribute to the cellular hallmarks of PAH, the importance of Gln metabolism is just beginning to emerge

Interestingly, TCA truncation increased the itaconate:succinate levels which limited LPS-induced M1 polarization [68]

Altered glutathione homeostasis in heart augments cardiac lipotoxicity associated with diet-induced obesity in mice