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In particular, the iodothyronine deiodinases (DIO) and glutathione peroxidases (GPX1) play an essential role in thyroid physiology and safeguard against diseases caused by immunological dysregulation and oxidative stress (OS) [6]

Finally, participants were filtered on relatedness such that no two people shared more than 700 cM identity by descent 37 , which corresponds approximately to the minimal expected sharing between first cousins in an outbred population, resulting in a final GWAS sample size of 15,237

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