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Abstract Glucagon-like peptide-1 (GLP-1) has a broad spectrum of biological activity by regulating metabolic processes via both the direct activation of the class B family of G protein-coupled receptors and indirect nonreceptor-mediated pathways

Its label also covers lowering the risk of major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease, and reducing the risk of worsening kidney function, kidney failure, and cardiovascular death in adults with type 2 diabetes and chronic kidney disease

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Caldarola, G

Safety Through In-Office Visits Every dose change is a clinical decision