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Tirzepatide is an injectable medication for weight loss in adults with obesity or overweight

26 years Pharmacotherapy While most pediatric obesity cases are polygenic and environmentally mediated, onset of severe obesity in infancy, particularly when accompanied by hyperphagia, poor satiety, may be a marker of monogenic or syndromic forms of features

Absolute contraindications to phentermine, regardless of GLP-1 status: Uncontrolled hypertension History of coronary artery disease or heart failure Uncontrolled hyperthyroidism Glaucoma History of substance use disorder (phentermine is Schedule IV) Use within 14 days of MAO inhibitors Pregnancy or planning pregnancy Age over 65 (relative contraindication) The GLP-1 alone may still be appropriate in many of these scenarios

A healthcare professional can provide personalized advice based on your medical history and current medications

EMBO J 24(3):510520