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Headache is reported by some users, typically mild and decreasing with continued use

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However, the enhanced density of mitochondria and upregulated mitochondrial complex IV activity in MS lesion sites are also observed to be associated with increased mitochondrial stress protein mtHSP70, suggesting that enhanced density of mitochondria in MS lesions might also contribute to the formation of free radicals and subsequent tissue damage (Witte et al., 2009)