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Immunohistochemistry and single cell RNA-sequencing confirm that intestinal Esm1 + cells have a distinct molecular profile and the capacity to undergo arterial differentiation

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In undifferentiated keratinocytes, VDR primarily regulates downstream target genes through interactions with the mediator (MED) complex [124].In more differentiated keratinocytes, VDR function is predominantly mediated via coactivators of the steroid receptor coactivator (SRC) family, particularly SRC2 and SRC3 [125]

IGF-1 has a longer half-life than growth hormone (about 12-15 hours), so it provides more sustained anabolic signaling even as GH levels fluctuate

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