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While this risk has not been confirmed in human epidemiological studies, patients with personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) should not use orforglipron or any GLP-1 receptor agonist
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They can produce a temporary skin-brightening effect by reducing melanin production and oxidative stress but they dont permanently whiten skin, and results differ between individuals
Prescribing physicians use a patients medical history and sometimes even initial and ongoing biomarker testing to assess candidacy
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