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Viceversa, in mice fed a high-fed diet inducing weight gain, hepatic steatosis and IR were accompanied by alterations in expression of hepcidin (a protein that regulates iron homeostasis in response to erythropoietic activity) which preceded dysregulation of iron concentrations particularly in liver and visceral adipose tissue, with no effect on serum iron levels (Varghese et al., 2020)

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