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Skin concerns: Uneven body tone, post-friction darkening on knees and elbows, dullness, and loss of radiance over time

However, at 12 months post-index the 3.0-mg dulaglutide dose reached a maximum dose distribution of 15.4% in cohort 1 and 17.3% in cohort 2

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However, both may affect appetite and nausea, so your prescriber needs to monitor symptoms closely during the first few weeks of semaglutide therapy