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Wet weight (mg) of liver per ml of total homogenate for each group of rats was calculated and using this value and concentration of GSH in liver cytosol fraction for each group, the GSH content of liver (moles g -1 wet weight) was determined as presented in Table 1
As such, the model was used to simulate how long it would take pharmacologically and toxicologically relevant concentrations of doxorubicin to yield a 70% reduction in GSH concentration, indicative of impaired cellular antioxidant defence, protein binding and cell death 19
Anti-Doping Agency (USADA) because of its potential to enhance recovery, endurance, and athletic performance (1)
They do not interfere with each other's absorption, metabolism, or excretion
They address key functions in the body and improve overall well-being
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