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In addition, aging cells show accumulation of metals such as copper and iron, often accompanied by impaired UPR mt and autophagy [155]

Transcriptomic analysis demonstrated anti-inflammatory and anti-apoptotic effects were through MAPK pathway inhibition, showing inhibited phosphorylation of ERKs, JNKs, and p38 MAPKs with downstream upregulation of BCL2 and downregulation of Bax, CASP-3 and cytochrome (cyt) C [139]

10.1016/j.lfs.2007.04.010 157 WangY.LiuN.BianX.SunG.DuF.WangB.et al (2015b)