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The incidence of malformations exceeded concurrent and historical controls at 0.01 mg/kg/day (kidneys, scapula), 0.01 mg/kg/day (eyes, forelimb), 0.025 mg/kg/day (brain, tail and sacral vertebrae, major blood vessels and heart, umbilicus), 0.025 mg/kg/day (sternum) and at 0.05 mg/kg/day (parietal bones, major blood vessels)

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Our study revealed that Sema treatment effectively suppressed pressure overload-induced pathological hypertrophy and cardiac dysfunction in male mice, a condition accompanied by significant mitochondrial damage in chronic HF induced by transverse aortic constriction (TAC)

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They may check for other causessuch as infection or medication interactionsand ensure youre not losing too much fluid or electrolytes