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Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for P53 activation and tumor suppression

The acronym GLP stands for glucagon-like peptide, a hormone your body naturally makes to help manage blood sugar and signal fullness after eating

Cell Host Microbe 28 , 586601.e586 (2020)

We're talking like five to 15% of a person's body weight in a year, and we think these GLP-1 like drugs work in part by traveling to the brain and triggering these molecular switches in parts of the brain that control appetite and hunger, they make people's brains feel full and they eat less

doi: 10.1210/en.2013-1735 28 UekiKOkadaTHuJChongWLAssmannADahlgrenGMet al