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Gastrointestinal symptoms (more common with oral preparations): Mild nausea or upset stomach Diarrhoea (typically with very high doses) Other effects: Headache, particularly when treatment is first initiated Dizziness or light-headedness Skin reactions such as mild rash or itching Temporary reddish discolouration of urine (chromaturia) after hydroxocobalamin injections, which is harmless It is important to note that many symptoms attributed to B12 supplementation may actually represent the body's response to correcting a deficiency

10.1016/j.trsl.2021.10.001 123 ZhangW.MiikedaA.ZuckermanJ.JiaX.CharugundlaS.ZhouZ.et al (2021a)

This review discusses the molecular mechanisms of ferroptosis in cancer and proposes new targets for clinical therapy

By week 8-12, many patients achieve 5-15 pound reductions, though individual results vary based on starting weight, diet consistency, and exercise habits

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