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This binding dramatically extends the peptide's half-life from minutes to approximately 68 days , allowing for sustained GH elevation with less frequent dosing

To determine how GLP-1R activation alters calcium dynamics in VTA GABA neurons during cocaine seeking, rats were pretreated with vehicle or exendin-4 (2.0 g/kg, i.p.) prior to a cocaine priming-induced reinstatement test session

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