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The ECD has been proposed to function as a negative regulator of GCGR 20

doi: 10.1038/s41392-022-01046-3 47

9 This study enrolled more than 7,400 high-risk individuals to evaluate two variations of the Mediterranean diet, one enriched with extra-virgin olive oil and the other with mixed nuts

This often leads to significant weight loss which is often noticed dramatically in the cheeks hence the trendy name Ozempic face facial wasting (fat loss) that occurs with precipitous weight loss from any cause

Wang et al, 2018