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To evaluate the contributions of mitochondrial pyruvate transport or long chain fatty acid oxidation to the effects of WY14643 on SC- cell formation, we exposed stage 6 SC-islets to WY14643 (or vehicle control) for 7 days in the presence or absence of the mitochondrial pyruvate carrier (MPC) inhibitor UK5099 or the CPT1A inhibitor etomoxir

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