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One suggested practice to managing GI AEs is the Three Es method, which comprises 1) education and explanation, 2) escalation to an appropriate dose, and 3) effective management of GI AEs

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Both of these factors are considered major drivers of biological aging

Overarching findings regarding background therapy adjustments to avoid hypoglycemia when initiating a GLP-1 RA include: (1) safe continuation of metformin regardless of baseline A1C or concurrent glycemic background therapy