Our study has limitations such as small sample size and evaluation of only acute effect, lack of assessment of liraglutide blood concentration, and recruitment of patients with only two stages of chronic kidney disease
However, amidst the spotlight on these medications efficacy, one fundamental aspect often slips under the radar: hydration
GLP-1 receptor agonists produce substantial and sustained reductions in food intake clinical trials show average body weight reductions of 1322% depending on the drug, driven by smaller portions, reduced appetite for high-fat and ultra-processed foods, and a shift toward more frequent but smaller eating occasions
JAMA 282:15681575 Clemmensen C, Chabenne J, Finan B et al (2014) GLP-1/glucagon coagonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet
In the glucagon receptor complex, the extracellular half of transmembrane helix 7 shifts outward by 4.56 and 3.02 compared to glucagon-like peptide-1 receptor and glucose-dependent insulinotropic polypeptide receptor structures, respectively [3]