[DOI] [PMC free article] [PubMed] [Google Scholar] 145.Al-Daghri N.M., Bukhari I., Yakout S.M., Sabico S., Khattak M.N.K., Aziz I., Alokail M.S
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I think we had all been expecting less, given that the launch of Novos previous obesity drug, Saxenda, wasnt very successfulalbeit with about 5% weight loss. However, investors have now definitely taken note, changing the landscape of pharma stocks
At the population level, GLP-1RAs have been shown to enrich SCFA-producing genera including Roseburia and Ruminococcus and promote Akkermansia muciniphila colonization (a bacterium whose bioactive protein P9 independently stimulates further GLP-1 secretion) while simultaneously suppressing pathobionts including Escherichia coli and Enterococcus by reducing endotoxemia and restoring barrier function
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