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Similarly, bile acid treatment rescued microbial diversity and restored 5-HT, DA, acetylcholine, BDNF, and tropomyosin receptor kinase B levels in both brain and gut of zebrafish, alleviating behavioral symptoms (Qian et al., 2025)

Dosing protocols are entirely experimental

A few reports do show T cell line or clone cytotoxicity toward isologous thyroid epithelial cells, and experimental thyroiditis can be transferred by lymphocytes

Mechanistically, TSA treatment increases the transcription levels of transcription factor EB (TFEB) and its downstream autophagy-lysosome pathway-related genes, including cystinosin and hermansky-pudlak syndrome 1

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