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The mean (s.d.) duration of exposure to semaglutide or placebo in the SELECT trial was 34.2 (13.7) months

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Although ALCAR exerts antioxidant activities in rodents, it is not known whether taking high doses of ALCAR will have similar effects in humans

Given that gut microbiota imbalances may contribute to AD progression by promoting amyloid-beta accumulation, triggering inflammation, increasing oxidative damage, and impairing insulin signaling 45,82 , these findings highlight the possibility that modulation of gut-brain axis may be a key mechanism underlying the cognitive benefits of dual-action therapies in DM2-AD comorbidity

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