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doi:10.1038/nrendo.2012.140 4.Meier JJ, Weyhe D, Michaely M, et al

The UK Reference Nutrient Intake for healthy adults is 1.5 micrograms daily, typically obtained through animal products or fortified foods

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Higher doses of tirzepatide may allow for engagement of the mGIPR, but it remains unclear whether these high doses alter the effect of the ratio of GLP-1R:GIPR activity, potentially confounding the interpretation of results