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In an in vivo study, depression like behaviors induced in rats by submitting to 8 weeks of chronic unpredictable mild stress (CUMS) leading to decreased expressions of -catenin, Bcl-2, GSH, and total antioxidant (TAC) as well as increased expressions of glycogen synthase kinase-3 (GSK-3), nuclear factor-kappa B (NF-kB), TNF-, IL-1, and MDA levels in hippocampus

An important aspect of this issue is that there can be a local deficiency of glutathione in the substantia nigra in the brain and also in muscle, and yet blood levels can be normal

Pang T, Wang YJ, Gao YX, Xu Y, Li Q, Zhou YB, et al

Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts