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However, it is noteworthy that, while upregulation of glutamine metabolism is a phenomenon present in many cancer cells, recent studies have shown a decrease in glutamine metabolism in cholangiocarcinoma, glioblastoma multiforme, liver hepatocellular carcinoma, and thyroid carcinoma, demonstrating tissue heterogeneity in glutamine metabolism [40]

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Chen, L., Wang, Y., Lin, J., Song, Z., Wang, Q., Zhao, W., Wang, Y., Xiu, X., Deng, Y., Li, X., Li, Q., Wang, X., Li, J., Liu, X., Liu, K., Zhou, J., Li, K., Liu, Y., Liao, S., Shan, G

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