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Johnson B, Haymaker CL, Parra ER, Soto LMS, Wang X, Thomas JV, Dasari A, Morris VK, Raghav K, Vilar E, Kee BK, Eng C, Parseghian CM, Wolff RA, Lee Y, Lorenzini D, Laberiano-Fernandez C, Verma A, Lang W, Wistuba II, Futreal A, Kopetz S , Overman MJ

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reported that humans who were administered GLP-1RA (liraglutide) lost weight and experienced a modest shift toward fat oxidation and decreased energy expenditure, indicating that human weight loss is primarily a result of a reduction in food intake caused by GLP-1R agonism [23]

Research has shown that individuals who go off of a GLP-1 drug tend to regain much of the weight lost