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Severe scarring requires additional treatments

JAMA (2013) 309:5707.10.1001/jama.2012.155925 105 JamesSJCutlerPMelnykSJerniganSJanakLGaylorDWet alMetabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism

Genes related to oxidative stress, ER stress, and apoptosis include Atf3, Ddit3, and Txnip

Tesamorelin, a more potent GHRH analog, has Phase 3 human trial data for visceral fat reduction in HIV-associated lipodystrophy, which provides some mechanistic validation for the class

Accessed July 16, 2026