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Steroidal saponin polyphyllin I (PPI) can induce apoptosis through caspase-dependent pathway and activate autophagy through PI3K/Akt/mTOR pathway

Author of the study and director of the Brain Mind Institutes Laboratory of Behavioral Genetics at EPFL in Switzerland, Professor Carmen Sandi, said, We found that the actual levels of the most important antioxidant in the nucleus accumbens- a part of the ventral striatum and a hub of the brain motivational system- determine the capacity to keep exerting effort over time to obtain rewardsour study suggests that the antioxidant system in the brain hub for motivation is critical to determine our capacity to keep going with tasks that require an effort but provide advantages for us/rewards. Does Motivation Depend only on Nutrition The reader should consider the studys limitations

Introduction The coronavirus disease 2019 (COVID-19) pandemic affected more than 602.8 million cases with more than 6.4 million deaths reported globally (The New York Times, 2022)

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