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Moreover, the most frequently experienced adverse effects included headache, itching and insomnia, which were never reported as being severe [7]

p = 0.01), decreasing from 64.2% to 62.1%

From a clinical perspective, the right time for reflux repair in patients with medication-induced or medication-worsened reflux is when conservative measures, such as drug therapy and lifestyle changes, fail to provide clear and significant symptom relief

Significance was determined by unpaired two-tailed Students t -test ( a , c , d )

Rapid dose escalation increases the chance of gastrointestinal side effects, which can cause patients to discontinue treatment altogether