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Again, thinking about the risk-benefit ratio can help

Advances in cryo-electron microscopy imaging of receptor structures, and the ability to create dynamic models to understand how the receptors change shape, are now crucial parts of GPCR drug discovery that allow initial in silico screens

Factors such as individual metabolism, overall health, and concurrent medications can all influence how one experiences fatigue while on GLP-1 therapy

The latest drugs also appear to reduce the risk or severity of some of the roughly 200 comorbidities linked to obesity including type 2 diabetes, hypertension and certain cancers but not all

Heterogeneity in the analyses vs active comparators could be attributed to differences in efficacy between the two GLP-1 RAs comparators (dulaglutide and semaglutide) or to differences in background glucose-lowering therapy between the two trials with basal insulin