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GPX4 genetic silencing in vitro The lentiviral plasmids, either non-targeted vector (pLKO.1-shNT) or pLKO.1-shGPX4 plasmid DNAs (Sigma-Aldrich) were transfected along with packaging and envelop plasmids psPAX2 and pMD2.G into HEK293T cells

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HMW1 and HMW2 are major NTHi adhesins present in 75-80% of isolates ( in vivo (Rempe et al., 2016)

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Throughout the treatment, our medical professional will make periodic checks of the IV site and your vital signs to ensure everything is progressing smoothly