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In clinical trials of semaglutide injection for type 2 diabetes mellitus (T2DM), cholelithiasis was reported in 1.5% and 0.4% of patients-treated with semaglutide 0.5 mg and 1 mg subcutaneous injection, respectively

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IGF-1 is also implicated in castration-resistant PCa and has been shown to activate androgen receptor (AR) signaling in prostate cancer cells via the IGF-1R-forkhead box protein O1 (FOXO1) signaling axis ( Figure 1 ) (5557)

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doi:10.3390/medicines8090046 20