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[10] Still, SGLT2 inhibitors increase risk of euglycemic diabetic ketoacidosis (DKA), and clinicians should ensure patients understand the DKA warning signs regardless of tirzepatide co-administration

The dose escalation protocol exists specifically to minimize these effects

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Several factors may hinder the absorption of natural food folate, e.g., partial release from the food matrix (incomplete liberation from cellular structures), destruction within the gastrointestinal tract, and incomplete hydrolysis of polyglutamates to monoglutamates (possibly mediated by partial inhibition of deconjugation enzymes by other dietary constituents such as organic acids)