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It appears to have both local and systemic effects depending on route of administration subcutaneous injection, oral supplementation (though oral bioavailability is debated), and local injection into injured tissue have all been studied in animal models

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(2) the ability of the TJ to selectively allow paracellular transport of certain ion species acting as ion channel and (3) the ability of the TJs to maintain cell polarity, by blocking the free diffusion of proteins and lipids between the apical and basolateral domains of the plasma membrane

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