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However, there are still challenges that need to be addressed, such as the optimization of properties, reliable characterization methods, safety evaluation, nanoparticles that might lead to unintended consequences like nano-pollution and cytotoxicity and regulatory aspects related to nanomedicines targeting skin cancer [176, 179]
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compared metabolites in synovial fluid and serum to identify potential biomarkers of joint injury in a mouse model of posttraumatic OA, shedding light on the pathophysiology of the disease [85]
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