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They also show promise for the treatment of many inflammatory diseases including asthma and inflammatory bowel disorders like Crohns disease and ulcerative colitis Diagram showing food stimulating the release of GLP-1 into the intestine and its effects on the brain, stomach and pancreas Importance In 2023 GLP-1 based drugs was named breakthrough of the year by Science , a prestigious American journal

It focuses on the mechanism of action of GLP-1R in pancreatic islet -cells, -cells and -cells, as well as its effects on the central nervous system and gastrointestinal tract

GLP-1 medications work by mimicking the naturally occurring hormone GLP-1, leading to improved blood sugar control and reduced appetite

A novel glucagon-like peptide-1 (GLP-1)/Glucagon hybrid peptide with triple-acting agonist activity at glucose-dependent insulinotropic polypeptide, GLP-1, and glucagon receptors and therapeutic potential in high fat-fed mice

The therapeutic potential of GLP-1 and its analogs extends beyond glycemic control and obesity management