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It was originally identified as a fragment derived from a larger protein found in human gastric juice, which sparked early scientific interest due to its unusual stability and biological activity under experimental conditions

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Thus, glutathione synthesis is linked to adequate availability of folate and other co-factors such as vitamins B6 and B12, as well as methionine, found in virtually all protein containing foods, and S-adenosylmethionine

Active pharmaceutical ingredients such as anastrozole (an aromatase inhibitor) or clomiphene citrate (a selective estrogen receptor modulator (SERM)) are sometimes used in male patients to manage secondary hypogonadism while preserving fertility