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Talking to Your GP or Prescriber About Side Effects All gastrointestinal side effects should be reported to your trial team or GP

This is a qualitative, mechanistic distinction between the two intervention categories, and it is why the research literature treats endpoint agonism and upstream secretagogue stimulation as fundamentally different manipulations of the somatotropic axis rather than two routes to the same outcome

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Int J Mol Sci 24(4):3384 Samms RJ et al (2021) GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice

These mechanisms typically produce modest reductions rather than dramatic drops