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The ROS cause the mitochondria to swell and disrupt their internal folded membranes, known as cristae, which house the electron transport chain
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In many cases, beneficial effects can be chalked up to antioxidant activity, while the coenzymes role in the electron transport chain can account for some others
Similarly, in the kidneys, lipid accumulation disrupts podocyte function and induces inflammation through toll-like receptor 4 (TLR4)-NF-B activation, exacerbating glomerular damage and chronic kidney disease (57)
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