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A major challenge in exploiting CRISPR-Cas9 to edit mtDNA mutations is the requirement for three enzymes to be synchronously expressed in the mitochondrial matrix for gene editing
It is important to choose a qualified healthcare professional trained in administering vitamin B12 shots
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Despite the detailed understanding of the physicochemical properties of NADs, the potential immunogenicity and toxicity of carriers and related modifications may pose additional challenges to safe and effective NADs delivery
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