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While BPA binding to extranuclear ER can trigger MAPK pathway activation 78 , the observed activation of the intracellular kinase pathways observed here more probably occurred via BPA binding to GPER, the G-protein coupled ER, as membrane bound ERs have not been identified in zebrafish 74

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Its unusual stability in acidic environments sets it apart from conventional peptides: the literature has reported a meaningful half-life at pH 2 and resistance to digestive proteases, making it a unique subject of study within the regenerative research peptide class

(PDF) Kim, N., Bloom, P.A., Rosellini, A.J., Webb, C.A., Pizzagalli, D.A., Auerbach, R.P

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