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The article says that once expiration dates pass, chemical bonds in the peptide weaken, reducing the drug's ability to activate GLP-1 and GIP receptors effectively

"Patients are more aware that now we have a few weapons in our arsenal to combat obesity, and [they] are seeking a multidisciplinary and holistic approach," Ghanem said

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Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy