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A primary mechanism is the disruption of the epithelial barrier via its virulence adhesin FadA, which binds to E-cadherin on host cells, leading to the activation of the NF-B pathway and the upregulation of pro-inflammatory cytokines such as TNF-, IL-1, and IL-6 (Li et al., 2021

doi: 10.1186/s43159-022-00189-w 4 NgJMunozDG

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"Basically no one apart from my mom wanted me to lose weight," she added