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All continuous predictors were grand-mean centered and 0.25% signal change using MATLABs findpeaks function 79

Among gut-derived uremic toxins, indoxyl sulfate and p-cresyl sulfate are largely protein bound in the blood circulation (mostly to albumin) and thus poorly cleared by diffusive dialysis procedures (75)

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This phenotype was defined by increased oxidative stress, presumably influenced by altered GM (e.g., reduced Bifidobacterium , elevated F/B ratio) and raised concentrations of FMO3 and TMAO