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The STEP trials showed sustained weight loss maintenance when patients remained on therapy, with some individuals achieving even greater reductions through consistent dosing and lifestyle support

The template (Figure 1) envisages permutations and combinations among the aforesaid factors plus oxidant attack on CFTR in ductular epithelium as determining outcome - whether recurrent acute pancreatitis, small-duct chronic pancreatitis, or large-duct disease with or without calculi

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Oxidative stress: an overview of past research and future insights

Recognized by WHO as the fifth leading global mortality risk factor, obesity serves as a primary pathogenic driver and exacerbating factor for multiple disorders, including cardiovascular diseases, diabetes mellitus, and specific malignancies