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However, it is important to note that curcumin has also been identified as a PAINS, exhibiting behaviors such as redox cycling, metal chelation, aggregation, and fluorescence interference that can artificially inflate its apparent bioactivity in vitro (Nelson et al., 2017)

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In the same study, in vivo experimentation using a transgenic mouse model further demonstrated SFNs robust influence by significantly inhibiting tumor growth and metastasis

3A, a substantial ten-fold increase in ALT activity was observed for 21NT after treatment with epitalon when compared with the untreated control

In contrast, loss of p53 prevents the accumulation of dipeptidyl-peptidase-4 (DPP4) in the nucleus, triggering membrane-associated DPP4-mediated lipid peroxidation