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Furthermore, heme can drive TNF-- and ROS-mediated necroptosis [225], heme oxygenase 1-dependent ferroptosis [226], and NLRP3 inflammasome-associated pyroptosis [227], which are highly proinflammatory RCDs

In a systematic review with meta-analysis that aimed to synthesize the existing knowledge between antioxidants and the pulmonary function of individuals with CF, the authors recommended the administration of NAC (primarily by inhalation) as an adjunct to treatment, as it became evident that oral supplementation of NAC exhibited beneficial effects in preventing deterioration of lung function, but not significantly

The authors hypothesized that glucose-based components of the dialysate could contribute to the stimulation of eryptosis [265]

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