Three points deserve attention first
Furthermore, MD revealed decreased flexibility of p53 TAD2 in complex with FOXO4-DRI compared to the FOXO4 FH -bound state with RMSDs of 1 heteronuclear NOE data was recorded using the HSQCNOEF3GPSI bruker pulse sequence (32 scans, 256 points in F1, 1024 points in F2, 1278.772 Hz spectral width in F1, 9615.385 Hz spectral width in F2) using a three seconds saturation period
This might be supported by the identification of this protein in two proteomic studies of mitochondrial protein fractions (Table 3) (Heazlewood et al., 2004
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The practical takeaway is that ERR appears to drive most skeletal-muscle effects, while ERR carries more of the cardiac signal